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. 2022 Feb 24;12:775132. doi: 10.3389/fonc.2022.775132

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Copyright © 2022 Cui, Xin, Li, Deng and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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piRNA hsa_piR_006613 suppresses the expression of FN1. (A) Software predicted the binding site between piRNA hsa_piR_006613 and FN1 mRNA 3’-UTR. (B) The expression of FN1 mRNA in U2OS and MG63 cell transfected with hsa_piR_006613 mimics or inhibitors analyzed by qRT-PCR. (D) The expression of FN1 protein in U2OS and MG63 cell transfected with hsa_piR_006613 mimics or inhibitors analyzed by western blot. (E) The luciferase assay confirmed that FN1 was the target of piRNA hsa_piR_006613. (F) Western blot analyzed the protein expression of FN1 in U2OS cell co-treatment with butorphanol and hsa_piR_006613 inhibitor. Data were expressed as mean ± S.D. of three independent experiments. “**” indicates P<0.01.