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. 2022 Mar 15;145(11):847–863. doi: 10.1161/CIRCULATIONAHA.121.057687

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© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Change in systolic blood pressure (mm Hg) after renal denervation in 6 prospective, randomized, sham-controlled trials.

ABPM indicates ambulatory blood pressure measurement; BP, blood pressure; RADIANCE HTN SOLO, Study of the ReCor Medical Paradise System in Clinical Hypertension in Absence of Hypertension Medications; RADIANCE-HTN TRIO, Study of the ReCor Medical Paradise System in Clinical Hypertension in the Presence of a Stabilized, Single Pill, Triple, Fixed Dose Antihypertensive Medication Regimen; SYMPLICITY HTN-3 trial, Renal Denervation in Patients With Uncontrolled Hypertension; SPYRAL HTN-OFF MED, Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-Electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications; SPYRAL HTN-OFF PIVOTAL, Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-Electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications Pivotal; and SPYRAL HTN ON MED, Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-Electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy. Adapted from references 15, 17–21.