Table 2.
Summary of the IS6110 sequences localised in preferential sites published for determined Mycobacterium tuberculosis families (Reyes et al., 2012; Comín et al., 2021).
| Strain | Lineage | Family by SIT | CN STRAIN | Number of IS6110 */studied (N = 74) | Mutated copies location | Mutation detected | Non-mutated copies location |
|---|---|---|---|---|---|---|---|
| HSJ 238 | L4.1.2.1 | Haarlem3 | HCN | 11/3 | - | - | Rv1754c,Rv0403c,Rv0963c |
| HMS 18009 | L4.1.2.1 | Haarlem3 | HCN | 10/2 | DR region | orfB Asp2Gly | Rv0403c |
| HMS18021 | L4.1.2.1 | Haarlem3 | HCN | 12/2 | - | - | Rv0403c,Rv0963c |
| HMS 18037 | L4.1.2.1 | Haarlem3 | HCN | 11/4 | Rv0963c | IR | Rv1754c,Rv2336, and Rv0403c |
| HCU 3729 | L4.1.2.1 | Haarlem3 | HCN | 7/5 | - | - | Rv1754c,Rv2336,Rv0403c,Rv0963c, and DR region |
| HMS 18031 | L4.1.2.1 | Haarlem3 | HCN | 8/2 | Rv0963c | orfB syn aa174 | Rv0403c |
| HMS 18022 | L4.1.2.1 | Haarlem1 | LCN | 6/4 | - | - | Rv1754c,Rv2336,Rv0403c, and Rv0963c |
| HMS 18007 | L4.1.2.1 | Haarlem1 | HCN | 10/1 | - | - | DR region |
| HMS 18046 | L4.1.2.1 | Haarlem1 | HCN | 9/4 | DR region | orfB Asp2Gly | Rv0963c,Rv1754c, and Rv0403c |
| HSJ 234 | L4.1.2.1 | Haarlem3 | HCN | 11/3 | Rv0963c | orfB syn103 | Rv2336,Rv0403c |
| HMS 18001 | L4.1.2.1 | Haarlem1 | HCN | 8/4 | - | - | Rv1754c,Rv0403c,Rv0963c, and DR region |
| HMS 18002 | L4.1.2.1 | Haarlem1 | HCN | 10/4 | - | - | Rv1754c,Rv2336,Rv0963c, and DR region |
| HMS 18005 | L4.3 | LAM3 | LCN | 5/1 | - | - | Rv3113 |
| HSJ 241 | L4.3 | LAM3 | HCN | 15/2 | - | - | Rv3113,DR region |
| HMS 18045 | L4.3 | LAM3 | HCN | 15/2 | - | - | Rv3113,DR region |
| HMS 18017 | L4.3 | LAM12 | HCN | 14/2 | - | - | lpqQ:Rv0836c,DR region |
| HMS 18025 | L4.3 | LAM9 | HCN | 11/2 | lpqQ:Rv0836c | orfB Gly123Arg | DR region |
| HMS 18010 | L4.3 | LAM9 | HCN | 14/2 | - | - | Rv1754c,DR region |
| HMS18047 | L4.3 | LAM4 | HCN | 14/1 | - | - | DR region |
| HMS 18048 | L4.3 | LAM9 | HCN | 10/3 | - | - | Rv1754c,lpqQ:Rv0836c, and DR region |
| HMS 18018 | L4.3 | LAM3 | HCN | 12/3 | - | - | Rv1754c,MT3426:MT3427, and lpqQ:Rv0836c |
| Ara217** | L4.3 | LAM9 | HCN | 13/2 | - | - | MT3426:MT3430,Rv1754c:cut1 |
| HMS 18019 | L4.4.1.1 | S | HCN | 11/1 | - | - | pks9 |
| HCU 3718 | L4 | T1 | HCN | 9/1 | - | - | DR region |
| HMS 18035 | L4 | T2 | LCN | 5/1 | - | - | DR region |
| HMS 18040 | L4 | T5 | HCN | 8/1 | - | - | DR region |
| HMS 18042 | L4 | T2 | HCN | 7/1 | - | - | DR region |
| HMS 18041 | L4 | T1 | HCN | 9/1 | - | - | DR region |
| HMS 18044 | L4 | T5_MAD2 | LCN | 6/1 | - | - | DR region |
| HMS 18014 | L4 | T5_MAD2 | LCN | 6/1 | DR region | orfA Thr67Iso | - |
| HMS 18038 | L3 | CAS1_DELHI | HCN | 16/1 | - | - | DR region |
| HCU 2828 | L6 | AFRI_1 | HCN | 8/1 | - | - | lipX:mshB |
| HCU 3775 | L6 | AFRI_1 | LCN | 3/1 | - | - | lipX:mshB |
| HMS 1693 | L6 | AFRI_1 | LCN | 3/1 | lipX:mshB | IR | - |
| HMS 14017 | L6 | AFRI_1 | LCN | 3/1 | lipX:mshB | IR | - |
| HMS 1942 | L6 | AFRI_1 | LCN | unk/1 | - | - | moaX |
| HMS 2000 | L6 | AFRI_1 | LCN | 5/1 | - | - | moaX |
| HSJ 66 | L6 | AFRI_1 | LCN | 3/1 | - | - | moaX |
CN, Copy number; HCN, high copy number; LCN, low copy number; and SIT, Spoligo International Type.
*
Total number of IS6110 based in the IS6110 RFLP pattern.
**
Outbreak strain (Comin et al., 2020).