Table 3.
Selected potentially significant ADEs and corresponding counts of associated DDI mechanisms.
| No. of associations | ADEs (HPO) |
|---|---|
| 6 mechanisms | Abnormal inflammatory response |
| 5 mechanisms | Neurological speech impairment |
| Dysphonia | |
| Abnormality of body weight | |
| Pancreatitis | |
| Abnormality of leukocytes | |
| Abnormality of bone marrow cell morphology | |
| Abnormality of erythrocytes | |
| Abnormality of cells of the erythroid lineage | |
| Pancytopenia | |
| Abnormality of multiple cell lineages in the bone marrow | |
| Thrombocytopenia | |
| 4 mechanisms | Abnormality of higher mental function |
| Growth abnormality | |
| Decreased body weight | |
| 3 mechanisms | Abnormal emotion/affect behaviour |
| Restlessness | |
| Thrombophlebitis | |
| Venous thrombosis | |
| Diabetes mellitus | |
| Increased body weight | |
| Seizure | |
| 2 mechanisms | Sleep disturbance |
| Ketosis | |
| Abnormal platelet count | |
| Rheumatoid arthritis | |
| Hematological neoplasm | |
| 1 mechanism | Abnormality of carbohydrate metabolism/homeostasis |
| Abnormal glucose homeostasis | |
| Hypoglycemia | |
| Abnormal thrombosis | |
| Diabetic ketoacidosis | |
| Excessive daytime somnolence | |
| Reduced consciousness/confusion | |
| Psychosis | |
| Abnormality of the urinary system physiology | |
| Leukopenia | |
| Acute kidney injury | |
| Renal insufficiency | |
| Abnormality of neutrophils | |
| Abnormality of prenatal development or birth | |
| Hepatomegaly | |
| Skin rash | |
| Multiple myeloma | |
| Metrorrhagia | |
| Menstrual irregularities | |
| Puberty and gonadal disorders | |
| Abnormality of female internal genitalia | |
| Abnormality of the cardiovascular system | |
| Arteriosclerosis | |
| Abnormality of the systemic arterial tree | |
| Lymphadenopathy | |
| Abnormality of the lymph nodes |