Table 1.
Baseline characteristics, pretransplant clinical features, and outcomes in the study cohort.
| Variables | Study cohort, n = 13 |
|---|---|
| Age, years† | 68 (66, 71) |
| Gender, male | 12, 92.3 |
| Height, inches† | 70 (68, 72.5) |
| Body mass index, kg/m2† | 26.6 (22.8, 28.9) |
| Lung transplant, bilateral | 12, 92.3 |
| Underlying diagnosis | |
| IPF | 9, 69.2 |
| COPD | 3, 23.1 |
| CPFE | 1, 7.7 |
| Pre-LTx clinical features | |
| LAS† | 47.5 (35.4, 54.7) |
| Creatinine, mg/dL† | 0.8 (0.8, 1.2) |
| Distance walked in six minutes, meters† | 346 (273, 393) |
| Right atrial pressure, mmHg† | 7.5 (4, 12.5) |
| Mean pulmonary artery pressure, mmHg† | 22 (20, 33) |
| Pulmonary capillary wedge pressure, mmHg† | 15 (6, 19) |
| Cardiac index | 3.3 (2.9, 3.7) |
| Known orthostatic hypotension | 1, 7.7 |
| Arrhythmia | 4, 30.8 |
| Preexisting peripheral neuropathy | 3, 23.1 |
| Preexisting gastroparesis | 2, 15.4 |
| Immunosuppression | |
| Induction: basiliximab | 10, 76.9 |
| Induction: rituximab/IVIG | 2, 15.4 |
| Induction: ATG | 1, 7.7 |
| Mycophenolate mofetil, tacrolimus, steroids | 13, 100 |
| Cyclosporin | 1, 7.7 |
| Belatacept | 1, 7.7 |
| Post-LTx clinical features | |
| Primary graft dysfunction grade 3 | 4, 30.8 |
| Time to endotracheal extubation, days† | 4 (1, 6) |
| Atrial fibrillation in first postoperative week | 9, 69.2 |
| Decrease in SBP supine to standing† | 56 (38, 66) |
| Decrease in DBP supine to standing† | 25 (10.5, 40) |
| Supine hypertension | 10, 76.9 |
| Discharged to home | 3, 23.1 |
| Inpatient rehabilitation after LTx | 10, 76.9 |
| Readmissions for inpatient rehabilitations | 3, 23.1 |
| Number of readmissions in first year† | 2 (1, 3) |
| Length of stay for readmissions, days† | 18 (13, 29) |
| Deaths | 6, 46.2 |
| 1st year | 3, 23.1 |
| 2nd year | 2, 15.4 |
| 3rd year | 1, 7.7 |
Data expressed as numbers, percentages unless specified otherwise; †data expressed as median (interquartile range). IPF, idiopathic pulmonary fibrosis; COPD, chronic obstructive pulmonary disease; CPFE, combined pulmonary fibrosis and emphysema; LTx, lung transplant; LAS, lung allocation score; IVIG, intravenous immunoglobulin; ATG, rabbit antithymocyte globulin; SBP, systolic blood pressure; DBP, diastolic blood pressure.