Table 2. Laboratory tests during individual PK profiling for patients with hemophilia B.

On FIX-SHL	Preinfusion	T = 15–30 minutes	T = 4 hours	T = 48–56 hours	T = 72–80 hours
On FIX-EHL	Preinfusion	T = 15–30 minutes	T = 4 hours	T = 24 hours	T = 72–120 hours	T = 168 hours a
ASAT	X
ALAT	X
GGT	X
LDH	X
AF	X
Albumin	X
Urea	X
Creatinine	X
Hemoglobin	X
Hematocrit	X
Thrombocytes	X
Blood group (if unknown)	X
Factor IX	X	X	X	X	X	X
Inhibitor FIX (only ≥ 18 years)	X
Bethesda FIX	X
Factor VIII	X
VWF:Ag	X
VWF:Act	X
VWF:CB	X
VWFpp	X
Buffy coat	X
APTT	X	X	X	X	X	X
PT + INR	X
Factor V	X
Fibrinogen	X
Max of 10 mL citrate plasma	X	X	X	X	X	X

Abbreviations: AF, alkaline phosphatase; ALAT, alanine aminotransaminase; APTT, activated partial thromboplastin time; ASAT, aspartate aminotransferase; EHL, extended half-life; FIX, factor IX; FV, factor V; FVIII, factor VIII; GGT, gamma-glutamyltransferase; INR, international normalized ratio; LDH, lactate dehydrogenase; PFA, platelet function assay; PK, pharmacokinetic; PT, prothrombin time; SHL, standard half-life; T, time point; VWF:Act, von Willebrand factor activity; VWF:Ag, von Willebrand factor antigen; VWF:CB, von Willebrand factor collagen binding; VWFpp, von Willebrand factor propeptide.

^aOnly in case of an EHL concentrate.