Most people with type 2 diabetes (T2D) will eventually undergo treatment intensification, often resulting in a more complex regimen that can negatively impact on both quality of life (QoL) and adherence.

Simplifying T2D therapy strategies, when suitable and without compromising treatment efficacy and safety, offers the opportunity to ease both disease and treatment burden, but is not always implemented in clinical practice.

Current treatment guidelines have a greater focus on intensification rather than on simplification, are mostly focused on the elderly, and lack clear guidance and examples on how simplification can be achieved.

Triggers for simplification should include a broad range of people, rather than just the elderly or the frail.

Where possible, simplification should be considered and regularly re-assessed for each individual with T2D receiving a complex insulin therapy regimen, with the aim of improving clinical outcomes, such as hypoglycaemic risk and QoL.