Fig. 8.

Liver metabolomic profiling by UPLC-QTOF/MS in the negative-ion mode (ESI-). (A) PCA score plot for the Control, Model and GLE-H groups; (B) PLS-DA score plot for the Control, Model and GLE-H groups; (C) OPLS-DA score plot for the GLE-H and Model groups; (D) S-loading plot based on the OPLS-DA analysis model of the GLE-H and Model groups; (E) Heatmap of relative abundance of significantly different metabolites (VIP value > 1.0, p < 0.05) between the Model and GLE-H groups; (F) Metabolic pathway impact prediction based on the KEGG online database. The -ln(p) values from the pathway enrichment analysis are indicated on the horizontal axis, and the impact values are indicated on the vertical axis.