Fig. 9.

Network visualization according to the Spearman's correlation coefficients between the key intestinal bacterial phylotypes and liver metabolites significantly regulated by GLE intervention. Red nodes: the key intestinal microbial phylotypes; green nodes: the liver metabolites (ESI+) significantly regulated by high-dose GAA intervention; blue nodes: the liver metabolites (ESI-) significantly regulated by high-dose GAA intervention. Red lines and black lines represent positive and negative correlations, respectively. Line width indicates the strength of correlation. Only the significant edges were drawn in the network based on Spearman's correlation (|r| > 0.5, P < 0.05). The identification information of liver metabolites in the positive and negative ion modes in the figure was shown in Supplementary Table. S1 and S2, respectively.