Table 1.

Clinical pathological information of NSCLC samples

Variables	Tumor PMR (%)	Para-tumor PMR (%)	Distant non-tumor PMR (%)	Tumor vs distant non-tumor			Para-tumor vs distant non-tumor
				P	P Adjusted		P	P Adjusted
The data was represented by the median (quartile). The P value and the PAdjusted value were calculated using a nonparametric Friedman test, and Padjusted a Bonferroni adjusted P value. P < 0.05 was in bold font. PMR: methylation reference percentage; LUAD: lung adenocarcinoma; LUSC: Lung squamous cell carcinoma
Age (yr)
≤60 (n=16)	1.480 (0.420, 8.380)	1.400 (0.739, 3.390)	0.445 (0.040, 0.958)	0.003	0.008		0.024	0.073
> 60 (n=28)	1.390 (0.432, 5.407)	1.380 (0.415, 3.120)	0.394 (0.108, 1.640)	0.002	0.006		0.201	0.604
Gender
Female (n=23)	0.726 (0.332, 2.580)	0.961 (0.513, 2.757)	0.200 (0.000, 3, 0.445)	0.001	0.002		0.007	0.022
Male (n=21)	1.605 (0.888, 94.555)	1.890 (0.501, 3.630)	1.310 (0.612, 2.010)	0.006	0.018		0.433	> 0.999
Smoking history
Never-smoker (n=34)	1.460 (0.417, 4.735)	1.280 (0.499, 2.765)	0.276 (0.009, 0.890)	0.002	0.005		0.067	0.2
Smoker (n=10)	1.400 (0.387, 151.425)	3.140 (0.585, 16.650)	1.315 (0.573, 2.652)	0.002	0.005		0.114	0.342
Histological type
LUAD (n=32)	1.030 (0.335, 4.735)	0.801 (0.302, 1.932)	0.295 (0.300, 0.950)	0.005	0.014		0.034	0.102
LUSC (n=12)	2.030 (1.237, 127.175)	2.970 (1.700, 3.470)	0.808 (0.042, 1.850)	0.001	0.004		0.186	0.558
Cancer location
Right lung (n=26)	1.345 (0.067, 6.137)	1.935 (0.515, 3.300)	0.699 (0.006, 1.317)	0.002	0.007		0.131	0.392
Left lung (n=18)	1.460 (0.456, 7.220)	1.120 (0.498, 1.890)	0.276 (0.480, 0.913)	0.002	0.007		0.059	0.178