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Comparison of the kinetic constants of ScPGM, PfPGM1 WT, and mutant proteins
| Kinetic constants | ScPGMa | PfPGM1 | PfPGM1 W68E | PfPGM1 P163A |
|---|---|---|---|---|
| KM 3-PG (μM) | 510 ± 60 | 182 ± 56 | 175 ± 64 | 197 ± 68 |
| kcat (s−1) | 380 ± 10 | 714 ± 68 | 215 ± 23 | 335 ± 35 |
| kcat/KM (M−1 s−1) | 7.4 × 105 | 3.9 × 106 | 1.2 × 106 | 1.6 × 106 |
The data for ScPGM was adapted from reference (17). The results represent mean ± SD of three independent experiments for PfPGM1 WT and mutant proteins.
