Table 2.

MICS of tafenoquine and reference compounds against dimorphous and filamentous fungi

Species/Strain	Tafenoquine MIC		Reference inhibitor MICS [ug/mL]
	50% inhibition	Complete suppression	Posaconazole	Voriconazole	Fluconazole
P. variotti MYA-3630	4	4	<0.03	NT	NT
Rhizopus arrhizus 99-880	4	4	1	NT	NT
R. arrhizus 99-892	4	4	0.25	NT	NT
R. arrhizus RA1	8	16	0.125	NT	NT
Sporothrix sp. Sporo1	2	4	0.06	NT	NT
Sporothrix sp. Sporo2	1	2	1	NT	NT
Sporothrix sp. Sporo3	2	4	0.06	NT	NT
Apophysomyces sp. Apo1	8	8	0.06	NT	NT
Apophysomyces sp. Apo2	2	4	<0.03	NT	NT
Apophysomyces sp. Apo2	16	32	0.5	NT	NT
Saksenaea sp. Sak1	4	8	<0.03	NT	NT
Saksenaea sp. Sak2	2	2	0.06	NT	NT
Saksenaea sp. Sak3	8	8	<0.03	NT	NT
Aspergillus flavus ATCC 204304	4	4	NT	1	NT
A. flavus Aflav2	8	16	NT	2	NT
A. flavus Aflav3	4	8	NT	1	NT
Aspergillus fumigatus AF93	8	16	NT	1	NT
A. fumigatus DI15-106	4	8	NT	> 16	NT
A. fumigatus DI15-116	4	4	NT	8	NT
Fusarium sp. FS1	8	16	NT	8	NT
Fusarium sp. FO1	8	16	NT	4	NT
Fusarium sp. FS2	16	16	NT	> 16	NT
Altenaria sp. Alt1	2	4	NT	2	NT
Curvularia sp. Curv1	2	8	NT	0.5	NT
Exserohilum sp. Exser1	4	8	NT	0.5	NT
Scedosporium sp. 00-180	4	8	NT	NT	0.125
Scedosporium sp. LP1	4	8	NT	NT	4
Scedosporium sp. Scedo1	4	4	NT	NT	0.125
Blastomyces dermatitidis Blasto1	1	2	NT	NT	<0.03
B. dermatitidis Blasto2	4	4	NT	NT	<0.03
B. dermatitidis Blasto3	8	8	NT	NT	<0.03
Emergomyces sp. Emerg2	4	4	NT	NT	<0.03
Emergomyces sp. Emerg3	2	4	NT	NT	<0.03
Histoplasma capsulatum HC1	4	4	NT	NT	0.125
H. capsulatum HC2	2	4	NT	NT	<0.03
H. capsulatum HC3	8	8	NT	NT	< 0.03
Coccidioides spp. Cocci1	4	8	NT	NT	16
Coccidioides spp. Cocci2	16	16	NT	NT	32
Coccidioides spp. DI17-143	16	16	NT	NT	4
Average (SD)	5.6 [4.2]	8.3 [6.1]	NC	NC	NC

NC = Not calculated, NT = Not tested.