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. 2022 Jan 28;41(11):1563–1575. doi: 10.1038/s41388-022-02192-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Binding of NFE2L3 transcription factor to IL33 and RAB27A/B loci in HCT116 CRC cells. a–c Location of NFE2L3 binding partners, MAFF and MAFK, DNA binding sites at the IL33 and RAB27A/B loci were established using the UCSC genome browser database and data from the ENCODE consortium [32], showing MAFF/K specific binding to IL33 and RAB27A/B loci in HEPG2 cells, respectively. Chosen peaks are marked in yellow. d–f Classical ChIP-qPCR analysis of NFE2L3 transcription factor binding to IL33 and RAB27A/B loci. HCT‐116 cells were analyzed by chromatin immunoprecipitation using antibodies against NFE2L3 or Rabbit preimmune serum to control for non‐specific binding. Data represent mean values ± SD; unpaired t‐test; *P < 0.05.