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. 2022 Jan 29;41(11):1622–1633. doi: 10.1038/s41388-022-02185-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A METTL3 expression of ICC tumor (n = 36) and normal tissue (n = 9) in GEPIA2 database. B METTL3 expression of ICC tumor (n = 27) and normal tissue (n = 27) in public dataset GSE107943. C METTL3 expression in ICC tumor (n = 27) and adjacent normal bile duct tissue (n = 8) were measured by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). D Representative immunohistochemistry (IHC) staining images of ICC tumors expressing low or high levels of METTL3. E Correlation analysis of METTL3 expression with tumor size (≤5 cm vs. >5 cm). F Correlation analysis of METTL3 expression with tumor, node, metastasis stages (stage I/II vs. III/IV). G Kaplan–Meier survival curves of disease-free survival (DFS) in 96 ICC patients, stratified by METTL3 IHC score (METTL3 low expression, n = 40 vs. METTL3 high expression, n = 56). The P value was calculated using the log-rank test. H Kaplan–Meier survival curves of overall survival (OS) in 96 ICC patients, stratified by METTL3 IHC score (METTL3 low expression, n = 40 vs. METTL3 high expression, n = 56). The P value was calculated using the log-rank test. I Multivariable analyses for overall survival were performed in the ICC cohort. *P < 0.05, ***P < 0.001, according to Student’s t test.