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. 2022 Jan 29;41(11):1622–1633. doi: 10.1038/s41388-022-02185-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The mRNA level of METTL3 after METTL3 silencing in HuCC-T1 and HCCC-9810 cells was confirmed by RT-qPCR. B The protein level of METTL3 after METTL3 silencing in HuCC-T1 and HCCC-9810 cells was confirmed by Western blotting. C Cell growth curve of HuCC-T1 and HCCC-9810 cells transfected with METTL3 shRNA or Control. D Colony-forming assays after METTL3 silencing in HuCC-T1 and HCCC-9810 cells. E Apoptosis analysis of HuCC-T1 and HCCC-9810 cells transfected with shControl or shMETTL3. F Cell cycle analysis of HuCC-T1 and HCCC-9810 cells transfected with shControl or shMETTL3. G Cell migration ability and cell invasion ability after shMETTL3-transfection in HuCC-T1 cell. H Xenograft tumors in each group were shown. The mice were sacrificed 28 days post-injection. I Tumor growth curves after the injection of shMETTL3 and Control HuCC-T1 cells. Tumor volume was calculated every 4 days. J Tumor weight of shMETTL3 and Control groups was measured. K Representative IHC staining of Ki67 in tumors with different treatments. L Representative images of TUNEL analysis in tumors with different treatments. The results are presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, according to a Student’s t test.