Table 2.
Patients with secondary cerebral ischemia—parameters related to successful and unsuccessful rescue therapy in terms of post rescue ischemic volume (volume with TTP delay > 4 s, T4 volume)
| T4 volume < 20 cc | T4 volume ≥ 20 cc | P-value | |
|---|---|---|---|
| Age (median, IQR) | 61 (54, 68) | 56 (46, 62) | 0.07 |
| Gender (% female) | 79% | 61% | 0.13 |
| Diabetes (%) | 7% | 0% | 0.28 |
| Hypertension (%) | 50% | 38% | 0.35 |
| WFNS grade (median, IQR) | 2(1, 4) | 2 (1, 4) | 0.52 |
| Fisher grade (median, IQR) | 4(3, 4) | 4 (2, 4) | 0.40 |
| Posterior circulation aneurysm (%) | 11% | 7% | 0.70 |
| Aneurysm size (mm, median, IQR) | 7(5, 10) | 7 (5, 14) | 0.26 |
| Aneurysm occlusion (% coiled) | 44% | 32% | 0.46 |
| Post occlusion WFNS (median, IQR) | 2 (2, 4) | 2 (1, 4) | 0.86 |
| Post occlusion T4 volume (median, IQR) | 9 (0, 30) | 10 (5, 58) | 0.07 |
| Day of decline (median, IQR) | 5 (2, 7) | 6 (3, 8) | 0.49 |
| T4 volume on day of decline (median, IQR) | 28 (10, 60) | 60 (40, 100) | 0.03 |
| Focal TTP delay on day of decline (mean ± STD) | 2.1 ± 1.5 s | 2.9 ± 2.1 s | 0.05 |
| Macrospasm on CTA (%) | 64% | 93% | 0.01 |
| Additional intra-arterial spasmolysis (%) | 18% | 25% | 0.56 |
| Post rescue T4 volume (median, IQR) | 5 (0, 10) | 30(23, 50) | 0.001 |
| Post rescue focal TTP delay (mean ± STD) | 1.3 ± 1.5 s | 2.4 ± 2.3 s | 0.01 |
| Resolution of macrospasm (%) | 42% | 44% | 1.0 |
| Secondary infarction (%) | 11% | 32% | 0.03 |
| mRS at 6 months (median, IQR) | 1 (1, 3) | 2 (1, 3) | 0.63 |