Table 4.

Comparative clinical studies using intravenous milrinone for vasospasm and DCI following aneurysmal subarachnoid hemorrhage

Author, year	Type of study	Total number of patients	Additional measures in milrinone group	Measures in control group	Primary outcome	Result
Soliman, 2019 [28]	Prospective, preventive, randomized	90	None, i.v. milrinone for 21 days	Intravenous magnesium for 21 days	TCD flow velocity < 120 cm/s, DCI	Magnesium better in terms of TCD and occurrence of DCI
Rouanet, 2021 [23]	Prospective, observational	21	None	Norepinephrine	TCD values and NIHSS at 45 and 90 min	TCD value lower in milrinone group, no clinical difference
Labeyrie, 2021 [13]	Retrospective two site comparison	200	Balloon angioplasty	Induced hypertension	1-month mortality, 6-month mRS 0–2, brain infarction	No or minimal difference between strategies
Lakhal, 2021 [14]	Retrospective historical comparison	94	Induced hypertension	Hypertension alone	6-month mRS 2–6, brain infarction	mRS 2–6 and infarction 75% lower in treatment group