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. 2021 Sep 15;33(1):135–142. doi: 10.1007/s00335-021-09917-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Pleiotropy across physiological systems and in relation to the effect size of the gene on the trait. Co-occurrence matrix of genes by physiological system for viable homozygotes (a) and heterozygotes (b), assessed with the early adult phenotyping pipeline, and lethal homozygotes (c), assessed with the embryo pipeline. Relationship between the total effect size of gene-trait associations in Euclidean distance versus the degreed of pleiotropy (d)