Fig. 1.

Timeline highlighting major milestones enabling complete functional annotation of the protein-coding fraction of the mouse genome. Technological advances that made possible the large-scale generation of mutant mouse resources are shown in black. Multi-institutional collaborative programs (e.g., European Mouse Disease Clinic; EUMODIC, and Knockout Mouse Phenotyping Program; KOMP²) implemented these advancements to perform high-throughput animal model production and systematic broad-based phenotyping. This collective work has grown to include additional international sites that have been centralized under the International Mouse Phenotyping Consortium (IMPC) to coordinate animal production, phenotyping, and data dissemination