Fig. 2.

Summary of mouse null allele production and progress towards completing a resource encompassing mouse–human orthologs. a Overview of animal production using either ES-cell based technology or CRISPR/Cas9 within independent research groups representing the Community effort or as part of the International Mouse Phenotyping Consortium. Dates for unique alleles generated by the Community were determined using earliest citation for allele transmission and dates for IMPC alleles were based upon record of successful confirmation of germline line transmission (GLT). b Histogram for null allele counts per gene shows that most genes have 1–3 unique null alleles while another ~ 2000 have 5 or more null alleles. c Contributions of different technology employed by the Community and IMPC to generate the null allele. d Venn diagram comparing all mouse genes with a null allele to the total number of mouse genes with a high-confidence human ortholog