Fig. 5.

GO term enrichment and pathway analysis on the set of 3381 genes classified into cell essential and nonessential categories. GO terms for a Biological process, b Cellular component, and c Molecular function highlight a role for essential genes in core biological processes including transcription, splicing, and translation, and a role for nonessential genes in metabolic processes and mitochondrial function. d KEGG pathway analysis supports the distinction between cell essential and nonessential genes and associated biological function. Enrichment values were determined using WebGestalt with FDR < 0.5