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a ΔDAS28, b DAS28 MCID,a c DAS28 remission, and d DAS28 LDA over 12 months. *p < 0.05, Dose-up vs Stay-on 5. aData are presented only for Dose-up and Stay-on 5 as MCID is not relevant in the context of dosing down Δ change from baseline, CI confidence interval, DAS28 4-component disease activity score in 28 joints, erythrocyte sedimentation rate, LDA low disease activity, LS least squares, MCID minimum clinically important difference, n number of evaluable patients
