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. 2022 Feb 25;13:826908. doi: 10.3389/fphar.2022.826908

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Copyright © 2022 Alhusaini, Fadda, Alanazi, Sarawi, Alomar, Ali, Hasan and Ali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Card and N-Resv ameliorate urea (A) and creatinine (B) after DXR-induced nephrotoxicity in rats. Data are expressed as mean $\pm$ SEM (n = 6). ^*** p $\leq$ 0.001 versus Control rats, ^### p $\leq$ 0.001, ^# p $\leq$ 0.05 versus DXR-intoxicated rats, and ^πππp $\leq$ 0.001 versus Card-treated rats.