Table 6.
Genotype | No | MO | MA/HM | CM | pMO | pMA | iETTH | fETTH | Others | Tot | |
---|---|---|---|---|---|---|---|---|---|---|---|
nDNA | DGUOK | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
MGME1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |
MICU1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |
OPA1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | |
POLG | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 7 | |
Likely nDNA | Multiple deletions | 1 | 2 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 6 |
mtDNA point | mtM | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
MELAS | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 6 | |
mtDNA deletion | Single deletion | 3 | 6 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 13 |
Total | All | 8 | 15 | 2 | 0 | 6 | 0 | 3 | 2 | 2 | 38 |
No no headache, MO migraine without aura, MA migraine with aura, HM hemiplegic migraine, CM chronic migraine, pMO probable migraine without aura, pMA probable migraine with aura, iETTH infrequent tension-type headache, fETTH frequent tension-type headache, DGUOK deoxyguanosine kinase, MGME1 mitochondrial genome maintenance exonuclease 1, MICU1 mitochondrial calcium uptake 1, OPA1 OPA1 mitochondrial dynamin like GTPase, POLG DNA polymerase gamma, mtM other point mtDNA mutations, MELAS mitochondrial encephalopathy, lactic acidosis and stroke-like episodes.