Figure 5.
Histopathological changes in hamsters infected and treated with equine anti-SARS-CoV-2 F(ab′)2 immunoglobulin. Cellularity (a), functional lung area (b), pneumonia (c), edema (d) and bronchitis (e) scores. Infiltration kinetics of leukocytes (f), neutrophils, and (g) mononuclear cells. Evolution of lesions in the bronchial epithelium (h). Data are presented as the means ± standard deviations of samples of six animals per group for the scores and five fields/images per slide. The data were analysed statistically with one-way ANOVA, followed by Tukey’s post-test. ***p < 0.0001; ** p < 0.001. Bar 10 µm; haematoxylin and eosin staining (H&E).