Table 3.
Diagnostic performance of clinical parameters in predicting autoimmune gastritis in the overall cohort.
| Clinical parameters | AUROC | SE | 95% CI | Cutoff value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|---|---|
| Endoscopic atrophic grade* | 0.909 | 0.031 | 0.848–0.970 | O3 | 87.1 | 89.7 | 46.6 | 98.5 | 89.5 |
| Disappearance of the gastric fold† | 0.773 | 0.054 | 0.66–0.879 | Disappearance of the gastric fold | 61.3 | 93.4 | 48.7 | 95.9 | 90.4 |
| Serum gastrin concentration (pg/mL) | 0.913 | 0.035 | 0.844–0.981 | 355 | 83.9 | 93.4 | 56.5 | 98.3 | 92.5 |
| Pepsinogen I (ng/mL) | 0.932 | 0.03 | 0.874–0.990 | 20.1 | 90.3 | 91 | 50 | 98.5 | 91 |
| Pepsinogen I/II ratio | 0.912 | 0.03 | 0.840–0.983 | 1.8 | 83.9 | 93.7 | 58.1 | 97.9 | 92.8 |
AUROC area under the receiver operating characteristic curve, 95% CI 95% confidence interval, NPV negative predictive value, PPV positive predictive value, SE standard error.
*Endoscopic atrophic grade was based on the Kimura–Takemoto classification (C0–O3), and O4 is defined as marked vascular visibility observed in the greater curvature of the corpus.
†P < 0.05 in comparison with the AUROC for the disappearance of the gastric fold, by the Delong test.