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. 2022 Mar 10;13:1251. doi: 10.1038/s41467-022-28898-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Proliferative responses against a SARS-CoV-2 proteins S1, S2, M, NP, ORF3 and ORF8 presented in CD4+ (Left hand panel) and CD8+ (Right hand panel) T cells measured at 28 and 180 days pso for volunteers with mild disease or days post PCR positivity for asymptomatic disease (asymptomatic n = 8, mild disease n = 49). A two-tailed Wilcoxon rank-sum test was used to compare between study time points and P values are indicated. b Unsupervised hierarchical clustering showing visual representation of SARS-CoV-2 specific responses at day 28 and 180 in both CD4+ and CD8+ T cell compartments and c comparative analysis of SARS-CoV-2 specific CD4+ and CD8+ T cell responses at day 28 (top panel) and day 180 (bottom panel) in both asymptomatic and mild groups (analysed as one group). Kruskal Wallis (one-way ANOVA on ranks) test, all P values are stated on plots. The boxplots all display the median values with the first and third quartile, and the whiskers represent the highest and lowest values no more than 1.5 times the interquartile range from the corresponding hinge.