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. 2022 Mar 10;12:3885. doi: 10.1038/s41598-022-07586-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A flowchart for the construction of the metabolic network using metabolite concentration from a proton magnetic resonance spectroscopy ( $^{1}$ H-MRS). (A) Concentration of each metabolite from $^{1}$ H-MRS acquired by a Bruker 9.4T scanner was estimated using LCModel. (B) Metabolic connection was defined as statistic association in the concentration between two metabolites. As an example of metabolic connections using concentration correlations used in the present study, we demonstrated that the concentration of PCr had a significant association with those of Cr and Glu. (C) The Correlation matrix was binarized by assigning one to entries above the threshold and 0 to entries under the threshold. Ala, alanine; Cr, creatine; PCr, phosphocreatine; GABA, $γ$ -aminobutyric acid; Glu, glutamate; Gln, glutamine; PCh, phosphorylcholine; GSH, glutathione; Ins, myo-inositol; NAA, N-acetylaspartate; Tau, taurine.