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. 2022 Feb 25;13:837443. doi: 10.3389/fimmu.2022.837443

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Copyright © 2022 Bellier, Saura, Luján, Molina, Luján and Klatzmann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bronchoalveolar IgA after an oral boost of intramuscularly vaccinated hamsters. Animals from Figure 5A , immunized by i.m. injection of VLPs pseudotyped with stabilized spike and VSP and formed in the presence or absence of SARS-CoV-2 M protein, were then boosted (+, squares) or not (-, cercles) with the same VLPs by oral route. Values represent the mean ± S.E.M. ***p < 0.001; ns, not significant; Mann Whitney tests comparing hamsters immunized with eVLPs formed with M or not and comparing hamsters orally boosted or not (n= 10).