Fig. 2.

Comparing and contrasting (A) fluorinated natural products (NPs) and (B) chlorinated, brominated and iodinated NPs.

A. Fluorinated NPs have only a single fluorine substituent and are typically analogs of biomolecules: I is 18‐fluorosteric acid, II is fluoroacetone, III is fluorocitric acid, IV is fluorothreonine, V is nucleocidin.

B. NPs Cl, Br, and I may contain multiple halogen substituents, examples with 4–6 per molecule are shown. VI, VII, and IX are marine natural products. VIII is sigillin A, a deterrent produced by a flea. X is the human hormone thyroxine.