Table 1.
Clinical characteristics of HNSCC datasets used in OShnscc
| Data source | Platform | Sample size | No. of deaths | Median age(years) |
Median OS (months) |
Male(%) | HPV status (+/-/NA) | StageI/II/III/IV/NA(%) | Smoking (%) | Tumor subsite | Survival term |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TCGA | Illumina HiSeqV2 | 523 | 220 | 61 | 21.50 | 73.04 | 35/239/249 | 5.16/13.96/15.68/51.05/14.15 | 75.14 | OC, OP,HP, L, T | OS, DSS, PFS, DFI, PFI |
| GSE10300 | GPL570 | 44 | 16 | 53 | 79.55 | 2.27/6.82/18.18/43.18/29.55 | 65.91 | OC, OP,HP, L | RFS | ||
| GSE27020 | GPL96 | 109 | 64 | 95.45 | 11.01/16.51/33.03/39.45/0 | 99.08 | L | DFS | |||
| GSE25727 | GPL8432 | 56 | 60 | 92.86 | 87.50 | L | DFS | ||||
| GSE31056 | GPL10526 | 96 | 36 | 59 | 13.54 | 62.50 | 0/20.83/3.13/37.50/38.54 | OC | OS, DFS | ||
| GSE3292 | GPL570 | 33 | 8 | 56 | 24.00 | 81.82 | 6.06/6.06/24.24/57.58/6.06 | OC, OP,HP, L | OS, DFS | ||
| GSE39366 | GPL9053 | 138 | 68 | 57 | 68.84 | 14/82/42 | 5.80/10.14/20.29/60.87/2.90 | 78.26 | OC, OP,HP, L | RFS | |
| GSE41613 | GPL570 | 97 | 51 | 26.30 | 68.04 | 0/97/0 | OC | OS, DSS | |||
| GSE65858 | GPL10588 | 270 | 94 | 59 | 27.90 | 82.59 | 73/196/1 | 6.67/13.70/13.70/65.93/0 | 88.52 | OC, OP,HP, L | OS, PFS |
| Total | 1366 | 493 |
HNSCC: head and neck squamous cell carcinoma; OShnscc: Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma; OS: overall survival; HPV: human papilloma virus; NA: not available; TCGA: The Cancer Genome Atlas; OC: oral cavity; OP: oropharynx; HP: hypopharynx; L: larynx; T: tonsil; DSS: disease-specific survival; PFS: progression-free survival; DFI: disease-free interval; PFI: progression-free interval; RFS: relapse-free survival; DFS: disease-free survival. PFS, DFI, and PFI were defined by Wichmann et al. (2015) and Liu et al. (2018).