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. 2022 Feb 25;13:846384. doi: 10.3389/fimmu.2022.846384

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Copyright © 2022 Han, Yuan, Cui, He, Wang, Zhuo, Yang and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HSC ameliorated LPS-induced ALI in mice. (A) The mice were treated with LPS (4 mg/kg, i.t.). After LPS injection, mice were treated with HSC at 0 and12 h, and the corresponding indexes were measured 24 h later. (B) Lung index (n=6); (C) White blood cells (WBC), (D) neutrophil and (E) lymphocyte counts in the blood, which were determined by an auto hematology analyzer (n=10), (F) Lung histopathology was assessed via H&E staining assay at 24 h after LPS challenge (200×) (n=6); ^### P < 0.001 compared to control alone group; ^* P < 0.05, ^** P < 0.01, and ^*** P < 0.001 versus the LPS group.