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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2021 Nov 26;195:114859. doi: 10.1016/j.bcp.2021.114859

Figure 1. CCL5 induces Nox1 expression and activation via CCR5 in vascular cells.

Figure 1.

Nox1, 2, and 4 gene expression from Rat Aortic Vascular Smooth Muscle Cells (RASMC) treated with CCL5 (100ng/mL, 8h and 24h) (A); Nox1 (B) and Nox4 (C) protein expression from RASMC treated with CCL5 (100ng/mL, 8h and 24h); Nox1 protein expression from RASMC treated with CCL5 (30–300ng/mL for 24 (D); p47phox protein content in membrane and cytosol fractions isolated from RASMC treated with CCL5 (100ng/mL, 30min and 60min) (E); Nox1 protein expression from RASMC treated with CCL5 (100ng/mL) in presence of maraviroc (40uM) (F); CCR1, 3, 5, and CCL5 gene expression from RASMC treated with CCL5 (100ng/mL, 8h and 24h). N=4–12. Data are presented as mean ± standard error of the mean (SEM). *P<0.05 vs vehicle; #P<0.05 vs CCL5+GKT771.