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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2021 Nov 26;195:114859. doi: 10.1016/j.bcp.2021.114859

Figure 4. CCL5 induces vascular proliferation by activating Nox1.

Figure 4.

Rat Aortic Vascular Smooth Muscle Cells (RASMC) staining for Edu (red) and nuclei (blue) after 24h of CCL5 treatment (100ng/mL) (A, B); PCNA (C) and Cyclin D1 (D) protein expression from RASMC treated with CCL5 (100ng/mL, 8h and 24h); Ki67 gene expression from RASMC treated with CCL5 (100ng/mL, 8h and 24h). Nox1 was inhibited by GKT771 (10uM). N=4–6. Data are presented as mean ± standard error of the mean (SEM). *P<0.05 vs vehicle; #P<0.05 vs vehicle. #P<0.05 vs CCL5+GKT771.