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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2021 Nov 26;195:114859. doi: 10.1016/j.bcp.2021.114859

Figure 5. CCL5 induces vascular inflammation and NFkB activation via Nox1.

Figure 5.

NFkB activation analyzed by immunostaining NFkB (green), phalloidin (red), nuclei (blue) in Rat Aortic Vascular Smooth Muscle Cells treated with CCL5 (100ng/mL, 60 min). Lipopolysaccharides (500ng/mL, 60 min) was used as a positive control (A); IL1β, TNFα, VCAM, and ICAM gene expression from RASMC treated with CCL5 (100ng/mL, 60 min). Nox1 was inhibited by GKT771 (10uM). N=3–4. Data are presented as mean ± standard error of the mean (SEM). *P<0.05 vs vehicle.