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Microbial dysbiosis-modulated protein mechanisms and autoimmune functions. (A) Microbe-mediated generation of protein aggregates reduces autophagic flux and thereby dysregulates the autophagosomal-lysosomal pathway. (B) Enteric infection triggers peripheral immune recruitment into the CNS by gaining access across the blood–brain barrier, thereby triggering an autoimmune attack on subsets of neurons (e.g., dopaminergic neurons).
