Table 1.
Clinical and biochemical data of the study population.
| Variable | PD n = 22 (f:54.5%; m:45.5%) | Controls n = 10 (f:40%; m:45.5%) | Significance | ||
|---|---|---|---|---|---|
| Mean | St.dev. | Mean | St.dev. | ||
| Age (y) | 57.4 | 11.2 | 63.3 | 10.2 | ns |
| Serum t-tau | 0.6 | 0.3 | 0.6 | 0.2 | ns |
| Aβ42 | 2.3 | 3.2 | 2.5 | 3.6 | ns |
| Aβ40 | 90.1 | 70.9 | 89.9 | 74.1 | ns |
| Aβ42/Aβ40 | 0.03 | 0.04 | 0.02 | 0.02 | ns |
| CSF t-tau | 240.8 | 137.3 | 214.1 | 115.5 | ns |
| p-tau | 35.6 | 18.0 | 33.7 | 13.1 | ns |
| Aβ42 | 669.1 | 291.2 | 723.9 | 277.6 | ns |
| Aβ40 | 9,863.9 | 3,160.9 | 8,276.6 | 3,728.9 | ns |
| Aβ42/Aβ40 | 0.07 | 0.02 | 0.09 | 0.04 | ns |
| AR | 8.7 | 3.8 | 15.3 | 17.4 | ns |
| Onset (y) | 53.8 | 12.7 | na | - | |
| Duration (y) | 5.0 | 4.8 | na | - | |
| MOCA | 23.1 | 5.2 | na | - | |
| UPDRS III | 22.4 | 14.5 | na | - | |
| NMSS | 24.4 | 21.6 | na | - | |
| LEDD | 319.1 | 418.2 | na | - | |
Biomarker concentration in serum and cerebrospinal fluid (CSF) is reported in pg/ml (m, male; f, female; y, years; ns, not significant; na, not applicable; other abbreviations are spelled out in the text).