Figure 4.
Quantitative data in nmol L−1 of individual CSF patient samples for tryptophan-kynurenine metabolites, arginine, neopterin and ratios in encephalitis patients (n = 10) in comparison with controls (n = 10). Comparison of the encephalitis and control groups were analysed by Mann-Whitney U test. (a) An increase was observed in kynurenine, 3-hydroxykynurenine, anthranilic acid, quinolinic acid and neopterin, whereas the levels of tryptophan, kynurenic acid, 3-hydroxyanthranilic acid and arginine decreased in encephalitis compared to controls (b) An elevation of tryptophan/kynurenine, quinolinic acid/kynurenine acid and anthranilic acid/3-hydroxyanthranilic acid ratios was observed in acute encephalitis.