Figure 3.

Linear topology of the membrane domain of human Band 3 showing its 14 TM structure with both the N− and C-termini on the cytoplasmic side of the membrane. The residues at the start and the end of the TM helices are shown. The TM segments in the core domain are shown in light brown and the segments in the gate domain in dark brown. TM3 and 10 are short helices that bind the substrate anion at their amino-terminal ends in the middle of the protein. Short helical regions joining TM segments are shown in blue (Adapted from Reithmeier et al., 2016).