Skip to main content
. 2021 Nov 4;71(2):264–274. doi: 10.2337/db21-0659

Figure 4.

Figure 4

More CD36 in Treg from subjects with prediabetes associated with higher expression of downstream transcriptional regulators but not mitochondrial genes. A: Schema of CD36-downstream transcriptional regulators and mitochondrial genes. GLUT1 and LDH (lactate dehydrogenase) regulate glucose metabolism; pyruvate entry into mitochondrial metabolism is not shown. CD36 (fatty acid translocase) mediates fatty acid uptake. SCD1 (stearoyl-CoA desaturase 1), ACLY (ATP-citrate lyase), ACC1 (acetyl-CoA carboxylase 1), FASN (fatty acid synthase), and SREBP-1 (sterol regulatory element binding protein 1) regulate fatty acid synthesis. CPT-1a (carnitine-palmitate transferase 1a) and ACAT1 (acetyl-CoA acetyltransferase 1) regulate fatty acid oxidation. PPARγ (peroxisome proliferator–activated receptor γ) regulates lipid metabolism and inflammation. PLIN2 (perilipin 2) regulates lipid droplet formation. ETC designates the mitochondrial electron transport chain CPT-1a (B), CD36 (C), or SREBP-1 (D) (precursor [P] or cleaved [C]) protein in stimulated T cell cultures as indicated. Panels B, C, and D show a representative Western blot; bar graphs show quantification of biological replicates. For all panels, N = 3 for each subject group and data (mean ± SD) were analyzed with two-way ANOVA. *P < 0.05; **P < 0.01; ***P < 0.005.