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. 2021 Nov 4;71(2):264–274. doi: 10.2337/db21-0659

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© 2022 by the American Diabetes Association

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CD36 mediates long-chain fatty acid uptake in Treg and total CD4⁺ T cell cytokine production by cells from subjects with prediabetes. A: BODIPY uptake in prediabetes Treg and stimulated Treg-Teff cocultures following pretreatment of Treg with the irreversible CD36 inhibitor SSO as indicated. Uptake is quantified based on mean fluorescence intensity of BODIPY FL C16 as quantified with flow cytometry. N = 4. B: Impact of Treg pretreatment with SSO on lactate production by CD4⁺ T cells from subjects with prediabetes. Examples of Th17 (C) or non-Th17 (D) cytokine production by CD4⁺ T cells as indicated after Treg pretreatment with SSO. For panels B–D, N = 5. All data are displayed as mean ± SD, with analysis by two-way ANOVA. *P < 0.05; **P < 0.01; ***P < 0.005.