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. 2021 Nov 29;71(2):298–314. doi: 10.2337/db21-0322

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© 2022 by the American Diabetes Association

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MG53 C14A knock-in mice retain intact cardiac IPC protection against I/R injury. A–C: Representative photographs (A) and statistical data of infarct size (n = 6) (B), and levels of LDH release in effluent (n = 13 WT + I/R, n = 11 MG53-C14A (ki/ki) + I/R, n = 7 WT + IPC + I/R, and n = 6 MG53-C14A (ki/ki) + IPC + I/R) (C) of WT and MG53-C14A (ki/ki) of the isolated perfused mouse hearts subjected to I/R ex vivo with or without IPC. Mg53 knockout (Mg53^−/−) mice subjected to I/R ex vivo with IPC were positive controls in panel B (n = 6 Mg53^−/− + IPC + I/R) and panel C (n = 4 Mg53^−/− + IPC + I/R). Scale bar is 2 mm. All data are presented as mean ± SEM. Statistical analysis was conducted by one-way ANOVA with Tukey multiple comparisons test (B) or two-way ANOVA with Tukey multiple comparisons test (C). NS, not significant.