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Potential mechanisms that may contribute to the cardiovascular benefit afforded by GLP-1Ra. GLP-1Ra-mediated cardioprotection likely results from multiple contributing factors, including a reduction in inflammatory processes and body weight, improvements in vascular function that decrease BP, attenuation of atherosclerosis, and cardiomyocyte-independent actions that improve myocardial function (see the text for references). VSMC, vascular smooth muscle cells.
