TABLE 1.

In vitro activities of THF carbapenems and comparative agents against gram-negative bacteria

Organism (no. of isolates)	Antibiotic	MIC (μg/ml)
		Range	50%	90%
Escherichia coli (30)	CL 188,624	0.06–0.12	0.06	0.12
	CL 190,294	0.03–0.06	0.06	0.06
	CL 191,121	≤0.015–0.06	0.03	0.03
	Biapenem	0.03–0.06	0.06	0.06
	Imipenem	0.12–0.25	0.12	0.25
	Meropenem	≤0.015–0.03	0.03	0.03
Escherichia coli, ceft-azidime resistant (15)	CL 188,624	0.03–0.25	0.06	0.25
	CL 190,294	0.03–0.5	0.12	0.25
	CL 191,121	0.03–0.5	0.03	0.25
	Biapenem	0.03–0.25	0.03	0.12
	Imipenem	0.12–1.0	0.12	0.25
	Meropenem	≤0.015–0.12	0.03	0.12
Klebsiella pneumoniae (15)	CL 188,624	0.06–0.5	0.06	0.25
	CL 190,294	0.06–0.5	0.12	0.12
	CL 191,121	0.03–1.0	0.12	0.25
	Biapenem	0.03–1.0	0.12	0.5
	Imipenem	0.06–1.0	0.25	0.25
	Meropenem	0.03–0.12	0.03	0.12
Klebsiella pneumoniae, ceft-azidime resistant (15)	CL 188,624	0.06–0.5	0.12	0.25
	CL 190,294	0.12–0.5	0.25	0.25
	CL 191,121	0.03–0.25	0.12	0.25
	Biapenem	0.03–0.25	0.12	0.25
	Imipenem	0.12–0.5	0.25	0.5
	Meropenem	0.03–0.12	0.06	0.06
Klebsiella oxytoca (15)	CL 188,624	0.03–0.25	0.12	0.25
	CL 190,294	0.03–0.25	0.12	0.25
	CL 191,121	0.03–0.25	0.12	0.25
	Biapenem	0.03–0.5	0.12	0.25
	Imipenem	0.12–0.5	0.25	0.5
	Meropenem	0.03–0.12	0.06	0.06
Serratia marcescens (15)	CL 188,624	0.12–0.5	0.25	0.5
	CL 190,294	0.12–0.5	0.25	0.5
	CL 191,121	0.25–4.0	1.0	2.0
	Biapenem	0.25–4.0	1.0	2.0
	Imipenem	0.25–4.0	1.0	4.0
	Meropenem	0.03–1.0	0.12	0.12
Enterobacter cloacae (11)	CL 188,624	0.03–0.25	0.12	0.25
	CL 190,294	0.06–0.25	0.12	0.25
	CL 191,121	0.06–0.5	0.12	0.25
	Biapenem	0.06–0.25	0.12	0.25
	Imipenem	0.5–2.0	0.5	1.0
	Meropenem	0.06–0.12	0.06	0.12
Enterobacter aerogenes (13)	CL 188,624	0.06–0.5	0.25	0.5
	CL 190,294	0.06–0.5	0.25	0.5
	CL 191,121	0.06–1.0	0.5	1.0
	Biapenem	0.06–1.0	0.25	0.5
	Imipenem	0.5–4.0	1.0	2.0
	Meropenem	0.03–0.12	0.06	0.12
Citrobacter freundii (15)	CL 188,624	0.03–0.5	0.12	0.25
	CL 190,294	0.06–0.5	0.06	0.25
	CL 191,121	0.03–1.0	0.12	0.5
	Biapenem	0.03–0.25	0.12	0.25
	Imipenem	0.12–2.0	1.0	2.0
	Meropenem	0.03–0.25	0.03	0.12
Citrobacter diversus (15)	CL 188,624	0.03–0.12	0.03	0.12
	CL 190,294	0.03–0.12	0.03	0.06
	CL 191,121	≤0.015–0.06	≤0.015	0.03
	Biapenem	0.03–0.12	0.03	0.06
	Imipenem	0.06–0.12	0.12	0.12
	Meropenem	≤0.015–0.03	≤0.015	0.03
Salmonella species (15)	CL 188,624	0.03–0.25	0.06	0.12
	CL 190,294	0.03–0.25	0.06	0.12
	CL 191,121	≤0.015–0.06	0.03	0.06
	Biapenem	≤0.06–0.12	0.03	0.06
	Imipenem	0.06–0.5	0.12	0.25
	Meropenem	≤0.015–0.06	0.03	0.06
Shigella species (15)	CL 188,624	0.12–0.5	0.25	0.25
	CL 190,294	0.12–0.5	0.25	0.25
	CL 191,121	0.25–0.5	0.25	0.5
	Biapenem	0.12–0.5	0.25	0.25
	Imipenem	0.25–0.5	0.25	0.5
	Meropenem	≤0.015–0.25	0.03	0.03
Morganella morganii (15)	CL 188,624	0.5–2.0	1.0	2.0
	CL 190,294	0.5–1.0	1.0	1.0
	CL 191,121	0.25–2.0	1.0	2.0
	Biapenem	0.25–2.0	1.0	2.0
	Imipenem	2.0–4.0	4.0	4.0
	Meropenem	0.06–0.5	0.25	0.5
Proteus mirabilis (15)	CL 188,624	0.25–2.0	1.0	2.0
	CL 190,294	0.25–2.0	1.0	2.0
	CL 191,121	0.06–2.0	1.0	2.0
	Biapenem	0.06–4.0	2.0	4.0
	Imipenem	0.12–4.0	2.0	4.0
	Meropenem	0.03–0.12	0.06	0.12
Providencia species (15)	CL 188,624	0.25–8.0	0.5	4.0
	CL 190,294	0.12–4.0	0.5	2.0
	CL 191,121	0.25–2.0	1.0	2.0
	Biapenem	0.25–2.0	1.0	2.0
	Imipenem	0.5–4.0	1.0	2.0
	Meropenem	0.06–1.0	0.06	0.12
Moraxella catarrhalis (15)	CL 188,624	≤0.015–0.06	0.03	0.03
	CL 190,294	≤0.015–0.06	0.03	0.06
	CL 191,121	≤0.015	≤0.015	≤0.015
	Biapenem	≤0.015–0.06	≤0.015	0.06
	Imipenem	≤0.015–0.06	≤0.015	0.06
	Meropenem	≤0.015	≤0.015	≤0.015
Burkholderia cepacia (12)	CL 188,624	2.0–8.0	8.0	8.0
	CL 190,294	4.0–16.0	8.0	16.0
	CL 191,121	4.0–16.0	8.0	16.0
	Biapenem	0.25–8.0	2.0	8.0
	Imipenem	1.0–16.0	8.0	16.0
	Meropenem	0.25–8.0	2.0	8.0
Stenotrophomonas malto-philia (20)	CL 188,624	256.0–>256.0	>256.0	>256.0
	CL 190,294	256.0–>256.0	>256.0	>256.0
	CL 191,121	256.0–>256.0	>256.0	>256.0
	Biapenem	256.0–>256.0	>256.0	>256.0
	Imipenem	256.0–>256.0	256.0	>256.0
	Meropenem	64.0–>256.0	256.0	256.0
Haemophilus influ-enzae (30)	CL 188,624	0.12–2.0	0.5	1.0
	CL 190,294	0.12–2.0	0.5	1.0
	CL 191,121	≤0.015–4.0	0.25	0.5
	Biapenem	≤0.015–4.0	0.5	1.0
	Imipenem	0.06–4.0	0.5	1.0
	Meropenem	≤0.015–0.12	0.06	0.06
Bacteroides fragilis (24)	CL 188,624	0.5–32.0	0.5	1.0
	CL 190,294	0.25–16.0	0.5	1.0
	CL 191,121	0.06–8.0	0.12	0.5
	Biapenem	0.06–0.5	0.25	0.25
	Imipenem	0.06–2.0	0.25	0.5
	Meropenem	0.06–4.0	0.25	1.0
Acinetobacter calco-aceticus (15)	CL 188,624	0.12–1.0	0.25	1.0
	CL 190,294	0.12–2.0	0.25	1.0
	CL 191,121	0.06–1.0	0.25	0.5
	Biapenem	0.03–0.25	0.12	0.25
	Imipenem	0.12–0.5	0.25	0.5
	Meropenem	0.12–1.0	0.5	1.0
Pseudomonas aeru-ginosa (30)	CL 188,624	2.0–>16.0	8.0	16.0
	CL 190,294	2.0–>16.0	8.0	16.0
	CL 191,121	1.0–16.0	4.0	8.0
	Biapenem	0.12–16.0	0.25	4.0
	Imipenem	0.5–16.0	1.0	4.0
	Meropenem	0.06–>16.0	0.5	8.0