TABLE 2.
In vitro activities of THF carbapenems and comparative agents against gram-positive bacteria
| Organism (no. of isolates) | Antibiotic | MIC (μg/ml)
|
||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| Streptococcus pneumoniae, penicillin susceptible (15) | CL 188,624 | ≤0.015–0.06 | ≤0.015 | ≤0.015 |
| CL 190,294 | ≤0.015–0.06 | ≤0.015 | ≤0.015 | |
| CL 191,121 | ≤0.015 | ≤0.015 | ≤0.015 | |
| Biapenem | ≤0.015–0.06 | ≤0.015 | ≤0.015 | |
| Imipenem | ≤0.015–0.03 | ≤0.015 | ≤0.015 | |
| Meropenem | ≤0.015–0.06 | ≤0.015 | ≤0.015 | |
| Streptococcus pneumoniae, penicillin intermediate (12) | CL 188,624 | 0.03–0.25 | 0.12 | 0.12 |
| CL 190,294 | 0.03–0.25 | 0.12 | 0.12 | |
| CL 191,121 | 0.03–0.25 | 0.12 | 0.12 | |
| Biapenem | 0.03–0.25 | 0.06 | 0.12 | |
| Imipenem | ≤0.015–0.12 | 0.03 | 0.12 | |
| Meropenem | 0.06–0.25 | 0.12 | 0.25 | |
| Streptococcus pneumoniae, penicillin resistant (15) | CL 188,624 | 0.06–2.0 | 1.0 | 2.0 |
| CL 190,294 | 0.12–2.0 | 1.0 | 2.0 | |
| CL 191,121 | 0.12–1.0 | 0.5 | 1.0 | |
| Biapenem | 0.12–1.0 | 0.5 | 1.0 | |
| Imipenem | 0.12–1.0 | 0.25 | 1.0 | |
| Meropenem | 0.5–2.0 | 0.5 | 2.0 | |
| Streptococcus pyogenes (15) | CL 188,624 | ≤0.06–0.12 | ≤0.06 | ≤0.06 |
| CL 190,294 | ≤0.06–0.12 | ≤0.06 | ≤0.06 | |
| CL 191,121 | ≤0.015 | ≤0.015 | ≤0.015 | |
| Biapenem | ≤0.015 | ≤0.015 | ≤0.015 | |
| Imipenem | ≤0.015 | ≤0.015 | ≤0.015 | |
| Meropenem | ≤0.015 | ≤0.015 | ≤0.015 | |
| Staphylococcus aureus, methicillin susceptible (15) | CL 188,624 | 0.25–0.5 | 0.25 | 0.25 |
| CL 190,294 | 0.06–0.25 | 0.12 | 0.12 | |
| CL 191,121 | 0.03–0.06 | 0.06 | 0.06 | |
| Biapenem | 0.03–0.12 | 0.06 | 0.12 | |
| Imipenem | ≤0.015–0.03 | ≤0.015 | 0.03 | |
| Meropenem | 0.12–0.25 | 0.12 | 0.25 | |
| Coagulase-negative staphylococcus, methicillin susceptible (15) | CL 188,624 | 0.12–1.0 | 0.25 | 0.5 |
| CL 190,294 | 0.03–0.5 | 0.12 | 0.25 | |
| CL 191,121 | ≤0.015–0.12 | 0.03 | 0.12 | |
| Biapenem | 0.03–0.25 | 0.06 | 0.12 | |
| Imipenem | ≤0.015–0.06 | ≤0.015 | 0.06 | |
| Meropenem | 0.06–0.5 | 0.12 | 0.5 | |
| Staphylococcus aureus, methicillin resistant (29) | CL 188,624 | 1.0–>16.0 | 16.0 | >16.0 |
| CL 190,294 | 0.5–>16.0 | 8.0 | >16.0 | |
| CL 191,121 | 0.06–>16.0 | >16.0 | >16.0 | |
| Biapenem | 0.12–>16.0 | >16.0 | >16.0 | |
| Imipenem | ≤0.015–>16.0 | >16.0 | >16.0 | |
| Meropenem | 0.25–>16.0 | >16.0 | >16.0 | |
| Coagulase-negative staphylococcus, methicillin resistant (15) | CL 188,624 | 2.0–>16.0 | >16.0 | >16.0 |
| CL 190,294 | 2.0–>16.0 | >16.0 | >16.0 | |
| CL 191,121 | 0.5–>16.0 | 16.0 | >16.0 | |
| Biapenem | 2.0–>16.0 | >16.0 | >16.0 | |
| Imipenem | 0.25–>16.0 | >16.0 | >16.0 | |
| Meropenem | 4.0–>16.0 | >16.0 | >16.0 | |
| Streptococcus agalactiae (15) | CL 188,624 | ≤0.015–0.06 | 0.03 | 0.03 |
| CL 190,294 | 0.03–0.06 | 0.06 | 0.06 | |
| CL 191,121 | ≤0.015–0.03 | ≤0.015 | ≤0.015 | |
| Biapenem | ≤0.015–0.03 | ≤0.015 | 0.03 | |
| Imipenem | ≤0.015 | ≤0.015 | ≤0.015 | |
| Meropenem | 0.03–0.12 | 0.06 | 0.06 | |
| Enterococcus faecalis (15) | CL 188,624 | 1.0–8.0 | 2.0 | 8.0 |
| CL 190,294 | 1.0–8.0 | 1.0 | 8.0 | |
| CL 191,121 | 0.25–2.0 | 0.5 | 1.0 | |
| Biapenem | 0.5–8.0 | 2.0 | 2.0 | |
| Imipenem | 0.25–2.0 | 1.0 | 1.0 | |
| Meropenem | 1.0–16.0 | 4.0 | 4.0 | |
| Enterococcus faecium (13) | CL 188,624 | 0.5–>128.0 | 8.0 | 128.0 |
| CL 190,294 | 0.5–>128.0 | 8.0 | 128.0 | |
| CL 191,121 | 0.25–128.0 | 8.0 | 64.0 | |
| Biapenem | 0.5–>128.0 | 32.0 | >128.0 | |
| Imipenem | 0.25–>128.0 | 8.0 | 64.0 | |
| Meropenem | 1.0–>128.0 | 32.0 | 128.0 | |