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. 2022 Feb 25;14:828457. doi: 10.3389/fnagi.2022.828457

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Copyright © 2022 Huang, Xu, Liu, Huang, Tan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inference of cell–cell communications by CellChat shows global alterations in signaling pathways-mediated communications between DaN and non-neuronal cells in PD. (A) Schematic diagram of cell–cell communication between DaN and non-neuronal cells. Circle plots of the interaction quantity (B) and interaction strength (C) between DaN and non-neuronal cells. Blue lines indicate that the displayed communication is decreased in PD, whereas red lines indicate that the displayed communication is increased in PD compared with healthy control. (D) Heatmaps of the interaction quantity (left panel) and interaction strength (right panel) between DaN and non-neuronal cells. Blue color indicates that the displayed communication is decreased in PD, while red color indicates that the displayed communication is increased in PD compared with healthy control.