Fig. 6.

Superposition between the TrxR domains of SmTGR and BmTrxR shown in transparency in black and grey cartoons, respectively, highlighting the different orientation of their relative Grx domains. The Grxs domains of BmTrx are in green while those of SmTGR are in magenta. On the left, it is possible to observe that the Grx domain of SmTGR has rolled over the TrxR domain, using α1 as a pivot, with respect to the Grx domain of BmTrxR. This results in a 180° rotation of the four-stranded β-sheet characteristic of the Grx fold (see Fig. S3). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)