Table 2.

Inhibition parameters of 25 nM BmTrxR (isoform D), 25 nM OvTrxR (isoform D) and 15 nM mammalian TrxR1 with auranofin, TRi-1 and TRi-2, based on data from Fig. 3C.

Inhibitor	Enzyme	Apparent IC50 (μM)a
Auranofin	BmTrxR	0.0024
	OvTrxR	0.0032
TRi-1	BmTrxR	0.013
	OvTrxR	0.012
	Mammalian TrxR1	0.012b
TRi-2	BmTrxR	1.8
	OvTrxR	1.5
	Mammalian TrxR1	2.144b

^aBased on enzyme activity in DTNB reduction assay.

^bData from [45].