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. 2022 Mar 11;12:4270. doi: 10.1038/s41598-022-08026-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Path diagrams representing the mediation effect of mechanical ventilation, lowest PaO2/FiO2, D-dimer peak, and length of hospital stay in the relationship between CRP peak and CT lung abnormalities at 2–3 months and between CRP integral and CT lung abnormalities at 6–7 months. θ1 is the estimated effect (Ln OR) of CRP descriptors on mechanical ventilation adjusting for confounders. θ2 is the estimated effect (Ln OR) of mediators on persistent lung abnormalities adjusting for confounders. β is the correlation coefficient of CRP descriptors on mediators. Confounders include age and sex. In the tables we report the decomposition of the effect of CRP descriptors on persistent lung abnormalities. OR, odds ratio; TE, total effect; NDE, natural direct effect; NIE, natural indirect effect; NIE/TE, % mediation proportion.