Table 2.
Models for CT abnormalities at 2–3 and at 6–7 months including age, sex, and standardized CRP curve descriptors alone (Model 1) and adding other standardized measures of disease severity not directly (or not only) linked to hyperinflammation: mechanical ventilation (Model 2), lowest PaO2/FiO2 (Model 3), D-dimer peak (Model 4), length of hospital stay (Model 5). Std, standardized; OR, odds ratio; CI, confidence interval; AUC, area under the ROC curve; CRP, C-reactive protein. For standardized variables we report OR for one standard deviation increase of the variable; for age we report the OR for one year increase.
| CT lung abnormalities at 2–3 months | CT lung abnormalities at 6–7 months | |||||||
|---|---|---|---|---|---|---|---|---|
| N | OR (95% CI) | P | AUC | N | OR (95% CI) | P | AUC | |
| Model 1 | 259 | 0.752 | 241 | 0.748 | ||||
| CRP peak std | 1.79 (1.23–2.62) | 0.003 | – | |||||
| CRP integral std | – | 2.24 (1.53–3.28) | < 0.001 | |||||
| Age | 1.07 (1.04–1.10) | < 0.001 | 1.06 (1.03–1.09) | < 0.001 | ||||
| Sex M | 1 | 1 | ||||||
| F | 0.80 (0.40–1.59) | 0.521 | 0.94 (0.51–1.75) | 0.843 | ||||
| Model 2 | 259 | 0.824 | 241 | 0.780 | ||||
| CRP peak std | 1.37 (0.94–2.00) | 0.099 | – | |||||
| CRP integral std | – | 1.86 (1.25–2.76) | 0.002 | |||||
| Age | 1.09 (1.05–1.12) | < 0.001 | 1.07(1.04–1.10) | < 0.001 | ||||
| Sex M | 1 | 1 | ||||||
| F | 0.73 (0.35–1.53) | 0.400 | 0.88 (0.46–1.67) | 0.692 | ||||
| Mechanical Ventilation | 7.13 (3.05–16.70) | < 0.001 | 3.32 (1.79–6.19) | < 0.001 | ||||
| Model 3 | 247 | 0.791 | 229 | 0.746 | ||||
| CRP peak std | 1.45 (0.97–2.18) | 0.073 | – | |||||
| CRP integral std | – | 2.25 (1.50–3.39) | 0.001 | |||||
| Age | 1.08 (1.05–1.11) | < 0.001 | 1.06 (1.04–1.09) | < 0.001 | ||||
| Sex M | 1 | 1 | ||||||
| F | 0.83 (0.39–1.77) | 0.630 | 0.93 (0.49–1.77) | 0.834 | ||||
| Lowest PaO2/FiO2 std | 0.45 (0.26–0.77) | 0.003 | 0.89 (0.67–1.20) | 0.453 | ||||
| Model 4 | 196 | 0.809 | 185 | 0.786 | ||||
| CRP peak std | 1.82 (1.13–2.93) | 0.013 | – | |||||
| CRP integral std | – | 2.03 (1.31–3.15) | 0.002 | |||||
| Age | 1.08 (1.04–1.12) | < 0.001 | 1.07 (1.04–1.10) | < 0.001 | ||||
| Sex M | 1 | 1 | ||||||
| F | 0.76(0.33–1.76) | 0.517 | 0.80 (0.38–1.69) | 0.566 | ||||
| D-dimer peak std | 1.68 (1.05–2.67) | 0.029 | 1.70 (1.19–2.42) | 0.003 | ||||
| Model 5 | 259 | 0.797 | 241 | 0.769 | ||||
| CRP peak std | 1.25 (0.84–1.88) | 0.275 | – | |||||
| CRP integral std | – | 1.70 (1.12–2.59) | 0.013 | |||||
| Age | 1.06 (1.03–1.09) | < 0.001 | 1.05 (1.03–1.08) | < 0.001 | ||||
| Sex M | 1 | 1 | ||||||
| F | 0.74 (0.36–1.54) | 0.421 | 0.89 (0.47–1.66) | 0.705 | ||||
| Length of hospital stay std | 2.21 (1.42–3.43) | < 0.001 | 1.72 (1.18–2.51) | 0.005 | ||||